منابع مشابه
Activation and reinactivation of inactive renin in normal human plasma.
Various facets of activation of inactive renin by acidification or cold exposure were investigated in normal human plasma. The acid activation obtained by titration was usually less than that by dialysis method, but varied from 41% to 122% of the latter. The acid phase of acid activation accounted for about 70% of the total activation achieved by the combined effects of the acid and alkaline ph...
متن کاملActivation of inactive plasma renin by plasma and tissue kallikreins.
1. Normal human plasma contains a proactivator of inactive renin. The pro-activator is activated at physiological pH in plasma that has been pretreated with acid. This activation in vitro leads to the conversion of inactive renin into the active form with simultaneous generation of kallikrein activity. 2. The endogenous activator of inactive renin has the same pH profile and inhibitor spectrum ...
متن کاملIsolation and activation of inactive renin from human kidney and plasma. Plasma and renal inactive renins have different molecular weights.
Inactive renin and active renin from human kidney and human plasma were prepared in highly purified forms by three steps of chromatography on Octyl-Sepharose, immunoaffinity chromatography, and pepstatin-amino hexyl Sepharose CL-4B. The inactive renin and active renin from human kidney had molecular weights of 51,000 and 44,000 as measured by a calibrated gel filtration column run with internal...
متن کاملRole of glandular kallikrein in the activation process of human plasma inactive renin.
Completely inactive renin was isolated from normal human plasma by DEAE-Sepharose column chromatography and Blue-Sepharose column chromatography. This inactive renin had a molecular weight of 54,000 daltons as determined by gel filtration on Ultrogel AcA 44. When the inactive renin was activated by trypsin, its molecular weight decreased to 48,000 daltons. The trypsin-activated renin differed f...
متن کاملKinetic comparisons of amniotic fluid inactive renin and renal renin using synthetic and human renin substrates.
Inactive renin has been isolated from pooled amniotic fluid and purified approximately 642-fold. Prior to activation the isolates had approximately 4% of the activity found after activation. The observation is similar to that reported for inactive renin from chorionic cell culture and suggests a placental origin of amniotic fluid inactive renin. Using plasma from an estrogen-treated woman, reni...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1979
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66926-x